Beneficial effects of plant extracts rich in polyphenols in the prevention of lipoperoxidation in rat

« Beneficial effects of plant extracts rich in polyphenols in the prevention of lipoperoxidation in rat and sheep given n-3 pufa enriched diet », Cécile Gladine, 2006.

The addition of n-3 PUFA in diets is recommended in animal husbandry to improve the health value of animal products. This feeding practice enhances lipoperoxidation but alters the health of animals as well as the quality of their products. In this context, it is recommended to add antioxidants in diets. 

4 Plant Extracts Rich in Polyphenols (PERP): rosemary, grape, citrus and marigold) have been selected in vitro because they were suitable to animal nutrition and potentially efficient. Their efficiency have been investigated in vivo in animals fed a n-3 PUFA-enriched diet, in association or not with vitamin E.

The bioefficiency of the 4 PERP has been studied in rats. After 3 weeks of treatment , each PERP enabled to reduce the lipoperoxidation at the plasmatic and hepatic level.

In sheep, after administrating as a single acute dose: 10% DM, the PERP improved the total antioxidative status of plasma and reduced lipid susceptibility to lipoperoxidation. 

The association of PERPs + Vitamin E has also been tested. PERPs were more efficient than Vitamin E to increase the resistance of plasma lipids to lipoperoxidation but the association of PERPs + Vitamin E improved the efficiency of peroxidated lipids reduction. The association of both types of antioxidants is necessary. 

Eventually, in case of oxidative stress, only the association vitamine E + PERP is efficient. 

Only the association of these two types of antioxidant efficiently prevents lipoperoxidation in animals fed with n-3 PUFA enriched diets and exposed to oxidative stress.